This advanced, 300-level paper is intended for cloud architects and senior leaders building workloads on AWS who are interested in using a multi-Region architecture to improve resilience for their workloads. This paper assumes baseline knowledge of AWS infrastructure and services. It outlines common multi-Region use cases, shares fundamental multi-Region concepts and implications around design, development, and deployment, and provides prescriptive guidance to help you better determine whether a multi-Region architecture is right for your workloads.