This whitepaper focuses on best practices for MQTT topic design in Amazon Web Services (AWS) Internet of Things (IoT). It covers how developing an optimal MQTT topic schema can improve the overall architecture and efficiency of your IoT solutions. It does so by providing greater visibility into cloud to device communication, providing more fine-grained security permissions, and enhancing integration options with other AWS IoT Core services (such as the AWS IoT Rules Engine, AWS IoT Device Shadow, AWS IoT Device Management, and AWS IoT Analytics). This whitepaper is intended for technical architects, IoT cloud engineers, and application architects. This paper assumes that the reader understands fundamental MQTT concepts and terminology.