This Guidance provides nonprofit organizations, health information exchanges, and healthcare provider networks a way to curate personal health information (PHI) on behalf of patients. Patient advocacy nonprofits serve as a PHI broker between patients and researchers. These nonprofits only share PHI if they have consent and can inform patients about specific research and discoveries derived from patient data. This reinforces a patient’s willingness to share PHI, accelerating research outcomes. This Guidance helps nonprofits ingest, transform, anonymize, and deliver PHI data to academic and commercial research development organizations, all while keeping the patient informed and protecting patient consent