This Guidance helps you send DICOM images directly to the cloud and store these images in Amazon Simple Storage Service (Amazon S3). This is accomplished by configuring a DICOM destination in your existing Picture Archiving and Communication System (PACS) or Vendor Neutral Archive (VNA) systems. The DICOM destination will be capable of receiving instances using DICOM Message Service Element (DIMSE). In this Guidance, image data is encrypted, and data storage is scalable to support variable workloads.