The Open Radio Access Network, or O-RAN, is an approach to transform the radio access network to a disaggregated, open, virtualized, and fully inter-operable mobile network. The O-RAN uses cloud technologies as its foundation to achieve the architecture goals and provide low-cost and fully automated 5G networks. AWS is an ideal cloud platform for the O-RAN network innovation, with more than 200 featured services and globally adopted infrastructure for telecom customers. This whitepaper explores the concept of the O-RAN, offers a reference architecture for the O-RAN on AWS, and presents best practices on Amazon Web Services (AWS) for key features of the O-RAN.