This paper acts as an introduction to the features, Amazon Web Services (AWS) services, and architectural components relevant when you back up an on-premises virtualization environment based on VMware vSphere to Amazon Simple Storage Service (Amazon S3). It shows examples that use products and features from AWS Backup and AWS Partner Network (APN) partners Veeam, Rubrik, Cohesity, and Druva to show you common approaches taken by AWS or APN Technology Partners. This paper is intended for solution architects familiar with VMware virtualization. You should have a knowledge level equivalent to a VMware Certified Professional in Data Center Virtualization for vSphere version (VCP-DCV).